ARPA Bio

 

What's is Alzheimer's Disease (AD) and what are the latest medical advances to treat the disease ?

Alzheimer’s disease is the most common form of dementia, a progressive neurodegenerative disorder that slowly impairs memory, thinking, and daily function due to loss of brain cells and buildup of abnormal proteins such as amyloid plaques and tau tangles. In 2025, the most promising advances include new monoclonal antibody therapies like lecanemab and donanemab, which target amyloid plaques and have been shown to slow cognitive decline if administered early in the disease. Other breakthroughs feature drugs and strategies that protect the blood-brain barrier, AI-powered therapies that restore neuronal function, and potential new interventions targeting tau pathology, neuroinflammation, and gene expression signatures. These advances mark a shift toward disease modification, early diagnosis via blood biomarkers, and combined personalized approaches, though challenges remain regarding side effects, accessibility, and tailoring treatments to individual patients.